一、建设目标

本中心瞄准国家营养与健康战略需求，开发现代精准营养创新技术与产品；通过现代原料学、前瞻微生物组学、多组学等手段，定向开展组分结构修饰，形成特色组分开发、新产品智能智造、靶向营养干预的全产业链技术体系，形成工、理、农、医等多学科交叉的理论研究与产业技术的整合与转化，实现新疆特色资源在多领域未来食品中的高附加值利用。

二、研究方向

1.应用多组学手段，集成机器学习和数学统计模型，多维多角度揭示目前与未来人类面临最大健康的诱因及关键生物标志物的筛选与建立，构建海量多组学数据资源体系，开发预测预警模型

2.以细胞、特色微生物为载体的活性物质合成地盘设计，结合结构导向的营养组分对肠道菌群谱及代谢产物的调控关系，通过精准营养设计，实现粪菌移植等新兴人类健康领域的新技术设计与新产品研发

3.基于AI、人工神经网络机器学习算法结合体内外筛选，开发新型生物传感，并构建人类健康跟踪分析系统，为重要慢病的预防和食物干预提供精准的健康管理，结合新疆特色生物、农业资源组分高通量筛选与挖掘，应用于人类健康饮食干预及未来食品的开发

三、团队组成

负责人：周中凯（国家级人才、教授、博导）

团队成员：宁明（副教授、博士）

          于朋（讲师、博士）

          吴浩天（讲师、博士）

黄卫宁（美国AACC国际院士，教授，博导，外聘）

高晓冬（中国科学院过程工程研究所，二级研究员/教授，博导，外聘）

四、在研科研项目

1.国家自然科学基金面上项目

2.国家自然基金地区联合基金重点项（合作方负责人）

3.科技部中欧科技合作基金

4.国家外专局高端外专项目

5.天津一带一路中俄合作低脂健康食品科技项目

6.科技部农业转化项目

7.科技部星火重点项目

8.天津市应用基础与前沿技术研究计划（重点项目）

9.国家重点研发计划生鲜食用农物流环境适应性及品质调控机制研究子课题

10.国家重点研发计划中华传统食品工业化加工关键技术研究与装备开发子课题

五、近五年代表性文章及专利

（一）文章

2022：

[1] Rui Wang, Jing Wang, Min Liu, Padraig Strappe, Mei Li, Anqi Wang, Min Zhuang, Jinguang Liu, Chris Blanchard, Zhongkai Zhou*. Association of starch crystalline pattern with acetylation property and its influence on gut microbota fermentation characteristics. Food Hydrocolloids, 2022, 128, 107556. JCR1 IF: 11.504

[2] Mei Li, Jing Wang, Fenfen Wang, Ming Wu, Rui Wang, Padraig Strappe, Chris Blanchard, Zhongkai Zhou* Zhou. Insights into the multi-scale structure of wheat starch following acylation: Physicochemical properties and digestion characteristics. Food Hydrocolloids, 2022, 124, 107347. JCR1 IF: 11.504

[3] Mei Li, Fenfen Wang, Jing Wang, Anqi Wang, Xuan Yao, Padraig Strappe, Zhongkai Zhou*, Qinghai Wu, Tianlong Guo. Starch acylation of different short-chain fatty acids and its corresponding influence on gut microbiome and diabetic indexes. Food Chemistry, 2022, 389, 133089. JCR1 IF: 9.231

[4] Ruge Cao, Xinru Liu, Xuqing Zhai, Lili Wang*, Zhongkai Zhou*. Preparation, investigation and storage application of thymol–chitooligosaccharide complex with enhanced antioxidant and antibacterial properties. Journal of the science of food and agriculture, 2022, 102(4): 1561-1568. JCR1 IF: 4.125

[5] Meng Jia, Xixi Wang, Jinguang Liu, Rui Wang, Anqi Wang, Padraig Strappe, Wenting Shang, Zhongkai Zhou*. Physicochemical and volatile characteristics present in different grain layers of various rice cultivars. Food Chemistry. 2022, 371, 131119. JCR1 IF: 9.231

[6] Rui Yang*, Tianhua Ma, Lina Shi, Qiaoe Wang, Liqun Zhang, Fenglu Zhang, Zhiwei Wang, Zhongkai Zhou*. The formation of phycocyanin-EGCG complex for improving the color protection stability exposing to light. Food Chemistry, 2022, 370, 130985. JCR1 IF: 9.231

[7] Fenfen Wang, Rui Yang, Jing Wang, Anqi Wang, Mei Li, Rui Wang, Padraig Strappe, Zhongkai Zhou*. Starch propionylation acts as novel encapsulant for probiotic bacteria: A structural and functional analysis. International Journal of Biological Macromolecules, 2022, 213, 11-18. JCR1 IF: 8.025

[8] Rui Yang, Mengge Gong, Siming Jiao, Juntian Han, Cui Feng, Meishan Pei, Zhongkai Zhou*, Yuguang Du*, Jianjun Li.* Protein Engineering of Pasteurella multocida α2,3-Sialyltransferase with Reduced α2,3-Sialidase Activity and Application in Synthesis of 3′-Sialyllactose. Catalysts, 2022, 12(6), 579.

[9] Zhen Dai, Jinguang Liu, Xuan Yao, Anqi Wang, Yuqian Liu, Padraig Strappe, Weining Huang, Zhongkai Zhou*. Association of gut microbiota characteristics and metabolites reveals the regulation mechanisms under Cd consumption circumstance. Journal of the Science of Food and Agriculture, 2022, 102(14), 6737-6748. JCR1 IF: 4.125

[10] Meng Jia, Dengdeng Li, Rui Wang, Anqi Wang, Padraig Strappe, Qinghai Wu, Wenting Shang, Xuanyu Wang, Min Zhuang, Chris Blanchard and Zhongkai Zhou*. Gut microbiota derived structural changes of phenolic compounds from colored rice and its corresponding fermentation property. Food & Function, 2022, 13(20), 10759-10768. JCR1 IF: 6.317

[11] Jacob Ojobi Omedi, Ning Li, Cheng Chen, Xin Cheng, Jing Huang, Binle Zhang, Tiecheng Gao, Li Liang, Zhongkai Zhou*, Weining Huang*. Potential Health Benefits of Yeast-Leavened Bread Containing LAB Pediococcus pentosaceus Fermented Pitaya (Hylocereus undatus): Both In Vitro and In Vivo Aspects. Foods, 2022, 11(21), 3416. https://doi.org/10.3390/foods11213416 JCR1 IF: 5.561

[12] Dan Zhou, Wenting Deng, Junhan Zhou, Hongying Deng, Jianxian Zheng*, Zhongkai Zhou*. Influence of alkylation and esterification of 2-(4-methoxyphenoxy) propionic acid on sweet inhibition property and its manipulating mechanism. International Journal of Food Properties, 2022, 26(1), 108-121. https://doi.org/10.1080/10942912.2022.2154610 

[13] Wenting Deng, Dan Zhou, Jiaxing Li, Jianxian Zheng*, Zhongkai Zhou*. A potent mechanism for revealing structurally manipulated sweetness inhibitory property of lactisole derivatives. Food Chemistry, https://doi.org/10.1016/j.foodchem.2022.134769 JCR1 IF: 9.231

[14] Ming Ning, Fengxian Tang, Jiluan Chen, Wen Song, Chunhui Shan. Physiological and transcriptomic analysis of postharvest Jiashi melon at different storage temperatures. Postharvest Biology and Technology. 2022, 191, 111963. JCR1 IF: 6.751

[15] Ming Ning, Fengxian Tang, Jiluan Chen, Qin Zhang, Xinxin Zhao, Chunhui Shan. Low temperature adaptation and preservation revealed by changes in physiological-biochemical characteristics and proteome expression patterns in post-harvest Hami melon during cold storage. Planta. 2022, 255(4), 1-14. JCR1 IF: 4.116

2021：

[1] Xiaojing Fan, Xin Jiao, Jinguang Liu, Meng Jia, Chris Blanchard, Zhongkai Zhou*. Characterizing the volatile compounds of different sorghum cultivars by both GC-MS and HS-GC-IMS. Food Research International. 2021, 140, 109975. JCR1 IF: 7.425

[2] Yuqian Liu, Jinguang Liu, Rui Wang, Hui Sun, Mei Li, Padraig Strappe, Zhongkai Zhou*. Analysis of secondary metabolites induced by yellowing process for understanding rice yellowing mechanism. Food Chemistry. 2021, 342, 128204. JCR1 IF: 9.231

[3] Jinguang Liu, Yuqian Liu, Meng Jia, Xuedong Kang, Saimin Wang, Hui Sun, Meng Liu, Anqi Wang, Padraig Strappe, Zhongkai Zhou*. Association of enriched metabolites profile with the corresponding volatile characteristics induced by rice yellowing process. Food Chemistry. 2021, 349, 129173. JCR1 IF: 9.231

[4] Rui Wang, Mei Li, Jinguang Liu, Fenfen Wang, Jing Wang, Zhongkai Zhou*. Dual modification manipulates rice starch characteristics following debranching and propionate esterification. Food Hydrocolloids. 2021, 119, 106833. JCR1 IF: 11.504

[5] Demei Meng, Lei Zhu, Liqun Zhang, Tianhua Ma, Yuyu Zhang, Lingyun Chen, Yimeng Shan, Yiwen Wang, Zhiwei Wang, Zhongkai Zhou*, RuiYang. Succinylated ferritin as a novel nanocage-like vehicle of polyphenol: structure, stability, and absorption analysis. Food Chemistry. 2021, 130069. JCR1 IF: 9.231

[6] Rui Yang, Jing Tian, Yuqian Liu, Lei Zhu, Jixuan Sun, Demei Meng, Zhiwei Wang, Chengtao Wang, Zhongkai Zhou*, Lingyun Chen. Interaction mechanism of ferritin protein with chlorogenic acid and iron ion: The structure, iron redox, and polymerization evaluation. Food Chemistry. 2021, 349, 129144. JCR1 IF: 9.231

[7] Rui Yang, Lei Zhu, Demei Meng, Qiaoe Wang, Kai Zhou, Zhiwei Wang, Zhongkai Zhou*. Proteins from leguminous plants: from structure, property to the function in encapsulation/binding and delivery of bioactive compounds. Critical Reviews in Food Science and Nutrition. 2021: 1-22. JCR1 IF: 11.208

[8] Ruge Cao, Xueyang Li, Zhongkai Zhou*, Zhenyu Zhao. Synthesis and biophysical analysis of Naringin-Chitooligosaccharide complex. Natural Product Research. 2021, 35(2): 305-311.

[9] Yumei Jiang, Na Zhang, Yawen Zhou, Zhongkai Zhou*, Yu Bai, Padraig Strappe, Chris Blanchard. Manipulations of glucose/lipid metabolism and gut microbiota of resistant starch encapsulated Ganoderma lucidum spores in T2DM rats. Food Science and Biotechnology. 2021: 1-10.

[10] Rui Wang, Mei Li, Padraig Strappe, Zhongkai Zhou*. Preparation, structural characteristics and physiological property of resistant starch. Advances in Food and Nutrition Research. 2021, 95: 1-40.

[11] Mei Li, Fenfen Wang, Jing Wang, Rui Wang, Padraig Strappe, Bo Zheng, Zhongkai Zhou*, Ling Chen*. Manipulation of the internal structure of starch by propionyl treatment and its diverse influence on digestion and in vitro fermentation characteristics. Carbohydrate Polymers. 2021, 270, 118390. JCR1 IF: 10.723

[12] Mei Li, Jing Wang, Fenfen Wang, Padraig Strappe, Wenting Liu, Jianxian Zheng, Zhongkai Zhou* Ye Zhang. Microbiota fermentation characteristics of acylated starches and the regulation mechanism of short-chain fatty acids on hepatic steatosis. Food & Function. 2021, 12, 8659-8668. JCR1 IF: 6.317

[13] Rui Wang, Fenfen Wang, Xuedong Kang, Jing Wang, Mei Li, Jinguang Liu, Padraig Strappe, Zhongkai Zhou*. Ultrasonication enhanced the multi-scale structural characteristics of rice starch following short-chain fatty acids acylation. International Journal of Biological Macromolecules, 2021, 190: 333-342. JCR1 IF: 8.025

[14] Jinguang Liu, Yuqian Liu, Anqi Wang, Zhen Dai, Rui Wang, Hui Sun, Padraig Strappe, Zhongkai Zhou*. Characteristics of moisture migration and volatile compounds of rice stored under various storage conditions. Journal of Cereal Science, 2021, 102, 103323.

[15] Lei Zhu, Lina Shi, Qiao-E Wang, Demei Meng, Zhongkai Zhou*, Rui Yang. Fabrication of ferritin-casein phosphopeptides-calcium shell-core composite as a novel calcium delivery strategy. Food & Function. 2021, 12(22): 11378-11386. JCR1 IF: 6.317

[16] Rui Yang, Mengyao Liu, Yuqian Liu, De-Mei Meng, Tianhua Ma, Cheng-Tao Wang, Jie Liu, Qiaoe Wang, Zhongkai Zhou*. The structure and stability analysis of the pea seed legumin glycosylated by oligochitosan. Journal of the Science of Food and Agriculture. 2021, 101(3): 1065-1075. JCR1 IF: 4.125

2020：

[1] Yue Xiao, Wenting Shang, Jinguang Liu, Hui Sun, Padraig Strappe and Zhongkai Zhou*. Analysis of the physiochemical properties of rice induced by postharvest yellowing during storage. Food chemistry, 2020, 306, 125517. JCR1 IF: 9.231

[2] Yuqian Liu, Jinguang Liu, Min Liu, Yaqi Liu, Padraig Strappe, Hui Sun, Zhongkai Zhou*. Comparative non-targeted metabolomic analysis reveals insights into the mechanism of rice yellowing. Food Chemistry, 2020, 308, 125621. JCR1 IF: 9.231

[3] Yuqian Liu, Jinguang Liu, Jing Kong, Rui Wang, Min Liu, Padraig Strappe, Chris Blanchard, Zhongkai Zhou*. Citrate esterification of debranched waxy maize starch: Structural, physicochemical and amylolysis properties. Food Hydrocolloids, 2020, 104, 105704. JCR1 IF: 11.504

[4] Jinguang Liu, Meng Liu, Yuqian Liu, Meng Jia, Saimin Wang, Xuedong Kang, Hui Sun, Padraig Strappe, Zhongkai Zhou*. Moisture content is a key factor responsible for inducing rice yellowing. Journal of Cereal Science, 2020, 102988. 

[5] Xiaoxu Zhang, Zhen Dai, Xiaojing Fan, Meng Liu, Jianfei Ma, Wenting Shang, Jinguang Liu, Padraig Strappe, Chris Blanchard, Zhongkai Zhou*. A study on volatile metabolites screening by HS‐SPME‐GC‐MS and HS‐GC‐IMS for discrimination and characterization of white and yellowed rice. Cereal Chemistry, 2020, 97(2): 496-504.

[6] Anqi Wang, Changhao Xiao, Jianxian Zheng, Chuansong Ye, Zhen Dai, Qinghai Wu, Jinguang Liu, Padraig Strappe, Zhongkai Zhou*. Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model. Journal of Functional Foods. 2020, 73, 104142.

[7] Yuqian Liu, Jinguang Liu, Anqi, Wang, Rui Wang, Hui Sun, Padraig Strappe, Zhongkai Zhou*. Physiological and proteomic analyses provide insights into the rice yellowing, Journal of Cereal Science, 2020, 95: 103048. 

[8] Demei Meng, Shengnan Chen, Jie Liu, Qiaoe Wang, Desheng Wang, Mengyao Liu, Zhongkai Zhou*, and Rui Yang*. Double-Interface Binding of Two Bioactive Compounds with Cage-Like Ferritin. Journal of Agricultural and Food Chemistry. 2020, 68(29): 7779-7788. JCR1 IF: 5.895

[9] Bo Zheng, Tongtong Wang, Hongwei Wang, Ling Chen*, Zhongkai Zhou*. Studies on nutritional intervention of rice starch-oleic acid complex (resistant starch type V) in rats fed by high-fat diet. Carbohydrate Polymers, 2020, 246, 116637. JCR1 IF: 10.723

[10] Demei Meng, Lina Shi, Lei Zhu, Qiaoe Wang, Jie Liu, Yu Kong, Muxin Hou, Rui Yang*, and Zhongkai Zhou*. Coencapsulation and Stability Evaluation of Hydrophilic and Hydrophobic Bioactive Compounds in a Cagelike Phytoferritin. Journal of Agricultural and Food Chemistry. 2020, 68(10): 3238-3249. JCR1 IF: 5.895

（二）专利

[1] 葡苷寡糖及其制备方法和应用，ZL202110550204.2。

[2] 耐热性高粘度的淀粉粘合剂及其制备方法，ZL201910172282.6。

[3] 一种利用蛋白酶制备脱脂豆粕贮铁多肽的方法和应用，ZL201811079344.0。

[4] 芦丁壳寡糖复合物及其制备方法和应用，ZL201811222615.3。

[5] 一种利用转谷氨酰胺酶及壳聚糖制备铁蛋白-壳聚糖复合物的方法，ZL201811293438.8。